Posted in Flagyl on December 27, 2014

Antibiotic susceptivity of Propionibacterium acnes isolated from orthopaedic infuse-associated infections

These authors investigated the susceptibleness of 55 clinical isolates of P. acnes, obtained from orthopaedic inculcate-associated infections of the knee join (n = 5), hip joint (n = 17), and shoulder joint (n = 33), to eight antimicrobial agents: benzylpenicillin, clindamycin, metronidazole, fusidic acid, doxycycline, moxifloxacin, linezolid and rifampicin. Synergy testing was likewise conducted, in which rifampicin was combined through each of the remaining seven antibiotics.

Phylogenetic typing based up~ tly sequence analysis showed that 31 isolates were printing character IA, 13 isolates type IB, and 11 isolates shadow II.

All isolates (n = 55) were susceptible to most of the antibiotics tested, with the exception of 100% check to metronidazole, five (9.1%) isolates displaying decreased susceptivity to clindamycin, and one (1.8%) to moxifloxacin.

None of the antimicrobial agents investigated were synergistic by each other when combined and nine isolates were antagonist for various antimicrobial combinations. The manhood of the antimicrobial combinations had one indifferent effect on the isolates of P. acnes. However, the connection of rifampicin and benzylpenicillin showed each additive effect on nearly half of the isolates.

Comment: This clause is very interesting from a calculate of standpoints:

(1) 22 of the 55 isolates came from haunch and knee infections – Propionibacterium is not accurate a shoulder issue
(2) Clindamycin is not universally effective against Propionibacterium. This is of importance in that many surgeons use this antibiotic toward prophylaxis.
(3) Rifampin appears to have existence a useful adjunct against Propionibacterium.

Here is some other important presentation regarding antibiotics and Propionibacterium. It makes the prominent observation that a significant percentage of the bacteria isolated from acne patients are now resistant to the greatest part common antibiotics used in acne usage: Clindamycin, Erythromycin, Tetracycline, Doxycycline and Minocycline. We have power to only assume that the same is truthful for the Propionibacterium found in failed arthroplasty.

As our infectious disease experts point out, we considering two worrisome trends: (1) there are fewer antibiotics beneficial to us for the prevention and management of infections and (2) the bacteria are seemly increasingly resistant to the antibiotics that we end have.


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