Posted in Flagyl on May 21, 2015

Real-globe data on Astellas’ Dificlir has shown that the avaricious-spectrum antibiotic significantly reduces recurrence and the whole of-cause mortality when used first-thread in all patients with Clostridium difficile taint.

Data from the CDI Service Evaluation study shows that, compared to traditionary broad-spectrum antibiotics, first-line application of targeted therapy Dificlir (fidaxomicin) in entirely CDI patients improved outcomes compared to practice in selected patients only.

The study looked at outer 1,450 patient episodes across seven hospitals in England that introduced Dificlir betwixt July 2012 and July 2013, and soon afterward compared the data with a retroactive cohort treated with broad-spectrum antibiotics vancomycin and metronidazole during the prior 12 months.

Two of these centres – A and B – used Dificlir while first-line treatment for all patients under which circumstances the other five only used it at the same time that first-line treatment in selected patients concerning both primary and recurrent CDI. Data collected in c~tinuance 177 patient episodes treated first-lineage with Astellas’ drug showed a weighty reduction in 28-day all-ground mortality, from 18.2% to 3.1% and 17.3% to 6.3% respectively.

The analysis also showed dramatically reduced resort rates: from 12.1% and 23.5% in centres A and B through standard of care treatments (vancomycin and metronidazole), to 3.1% in both these centres where Dificlir was used before anything else-line, the firm said.

On the cost side, adopting Dificlir as a primeval-line therapy for all patients generated savings of £19,490 at midst A, based on five recurrences avoided since every 50 patients, and £121,144 at the approve site, based on 10 recurrences avoided per 50 patients .

Last year Astellas published tools and materials of another real-world study carried completely at St George’s Hospital in London, England, also showing that Dificlir led to a conquest in recurrence of CDI and a without disrespect to of more than £48,000 against treatment with vancomycin or metronidazole.

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