Posted in Flagyl on May 15, 2015


Background: Plasminogen fault is a rare autosomal recessive infirmity, which is associated with aggressive periodontitis and gingival enlargement. Previously described treatments of plasminogen shortage associated periodontitis have shown limited issue. This is the first case hearsay indicating a successful therapy approach consisting of a non-surgical supra- and subgingival debridement in cabal with an adjunctive systemic antibiotic therapy and a severe supportive periodontal regimen over an note period of 4 years.Case presentationThe intraoral observation of a 17-year-old Turkish of ~s with severe plasminogen deficiency revealed generalized increased pouch probing depths ranging from 6 to 9 mm, blood-letting on probing over 30%, generalized tooth fickleness, and gingival hyperplasia. Alveolar bone privation ranged from 30% to 50%. Clinical etc. see the preceding verb loss corresponded to pocket probing depths. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, Prevotella intermedia, Prevotella nigrescens and Eikenella corrodens possess been detected by realtime polymerase bond reaction. Periodontal treatment consisted of replete mouth disinfection and adjunctive systemic distribution of amoxicillin (500 mg tid) and metronidazole (400 mg tid). A harsh supportive periodontal therapy regimen every three month in terms of supra- and subgingival debridement was rendered. The reported therapy has significantly improved periodontal freedom from disease and arrested disease progression. Intraoral observation at the end of the observance period 3.5 years after non-surgical periodontal therapy showed generalized decreased endure probing depths ranging from 1 to 6 mm, blood-letting on probing lower 30%, and tooth nimbleness class I and II. Furthermore, microbiological separation shows the absence of Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola from therapy. Conclusion: Adjunctive antibiotic treatment may transform the oral microbiome and thus, the inflaming response of periodontal disease associated to plasminogen deficiency and diminishes the risk of pseudomembrane production and progressive attachment loss.This ~-ending report indicates that patients with plasminogen failing may benefit from non-surgical periodontal manipulation in combination with an adjunctive antibiotic therapy and a stern supportive periodontal therapy regimen. Digg Facebook Google StumbleUpon Twitter

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