GENERIC NAME: metronidazole
BRAND NAME: Flagyl
DRUG CLASS AND MECHANISM: Metronidazole is every antibiotic effective against anaerobic bacteria and unquestioned parasites. Anaerobic bacteria are single-celled, subsistence organisms that thrive in environments in what one. there is little oxygen (anaerobic environments). Anaerobic bacteria be possible to cause disease in the abdomen (bacterial peritonitis), liver (liver pustule), and pelvis (abscess of the ovaries and the Fallopian tubes).
Giardia lamblia and ameba are intestinal parasites that can cause abdominal agonize and diarrhea in infected individuals.
Trichomonas is a vaginal pick-thank that causes inflammation of the vagina (vaginitis). Metronidazole selectively blocks more of the functions within the bacterial cells and the parasites resulting in their exit.
The FDA approved metronidazole tablets in July 1963.
PRESCRIBED FOR: Metronidazole is used to ~ of parasitic infections including Giardia infections of the unintellectual intestine, amebic liver abscess, and amebic bloody flux (infection of the colon causing bloody diarrhea), bacterial vaginosis, trichomonas vaginal infections, and carriers of trichomonas (the one and the other sexual partners) who do not wish symptoms of infection.
Metronidazole is in addition used alone or in combination by other antibiotics in treating abscesses in the liver, pelvis, abdomen, and brain caused by susceptible anaerobic bacteria.
Metronidazole is moreover used in treating infection of the colon caused by a bacterium called C. difficile. Many commonly-used antibiotics can alter the type of bacteria that live in the colon. C. difficile is each anaerobic bacterium that can infect the colon at what time the normal types of bacteria in the colon are inhibited by common antibiotics. This leads to anger of the colon (pseudomembranous colitis) with severe diarrhea and abdominal pain.)
Metronidazole also is used in combination with other drugs to treatHelicobacter pylori (H. pylori) that causes appetite or intestinal ulcers.
Metronidazole topical gel is used in spite of treating acne rosacea.
Metronidazole vaginal gel is used conducive to treating bacterial vaginosis.
SIDE EFFECTS: Metronidazole is a available antibiotic and is generally well tolerated by appropriate use.
Minor side effects contain:
Serious side effects of metronidazole are rare and the drug should be stopped if these symptoms appear:
GENERIC AVAILABLE: Yes
Tablets: 250 and 500 mg.
Tablets, extended extricate: 750 mg.
Capsule: 375 mg. Cream: 0.75% and 1%.
Gel: 0.75% and 1%.
Injection: 5 mg/ml
STORAGE: Metronidazole should exist stored at room temperature and protected from buoyant.
DOSING: Metronidazole may be taken orally through or without food. In the hospital, metronidazole be possible to be administered intravenously to treat grave infections. The liver is primarily answerable for eliminating metronidazole from the carcass, and doses may need to have ~ing reduced in patients with liver complaint and abnormal liver function.
Various metronidazole regimens are used. Some examples are listed among the shades.
Amebic dysentery: 750 mg orally 3 general condition of affairs daily for 5-10 days
Amebic liver abscess: 500-750 mg orally three epochs daily for 5-10 days
Anaerobic infections: 7.5 mg/kg orally or ~ means of injection every 6 hours for 7 to 10 days not to be superior to 4 grams daily.
Bacterial vaginosis: 750 mg (extended free tablets) once daily for 7 days or 500 mg twice daily for 7 days or 2 g sincere dose orone applicator-full of 0.75% vaginal gel, once or twice daily for 5 days.
Clostridium difficile contamination: 250-500 mg orally 4 spells daily or 500-750 orally 3 ages daily
Giardia: 250 mg orally three state of things daily for 5 days Helicobacter pylori: 800-1500 mg verbally daily for several days in compound with other drugs.
Pelvic inflammatory malady (PID): 500 mg orally twice daily for 14 days in combination through other drugs.
Trichomoniasis: 2 g uncompounded dose or 1 g twice Rosacea: put topical gel 0.75-1% formerly daily
Medically Reviewed by a Doctor up~ 12/17/2014
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