Posted in Flagyl on July 27, 2015

Recalcitrance of bacterial vaginosis among herpes-simplex-virus-type-2-seropositive women.

Stoner KA1, Reighard SD, Vicetti Miguel RD, Landsittel D, Cosentino LA, Kant JA, Cherpes TL.

1Departments of Obstetrics and Gynecology and Reproductive Sciences Pediatrics Medicine Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.




The multifactorial etiology of bacterial vaginosis (BV) impedes progression in a continuously ascending gradation of effective treatment and prevention strategies. Herein, we evaluated the effects of herpes simplex virus type 2 (HSV-2), a suspected BV put in peril factor, on vaginal flora composition.


  Correlations betwixt HSV-2 infection and BV were in the future explored among 12 HSV-2-seropositive women with asymptomatic BV who were asked to consider probable daily vaginal swab specimens for Gram tarnish analysis of vaginal flora and limitation of HSV-2 shedding frequencies for the period of the 1month before and after metronidazole therapy.


Unlike former longitudinal studies that reported rapid fluctuations in vaginal vegetable life composition and frequent episodes of spontaneously resolving BV, we originate that 99.4% (310/312) of vaginal smears collected before commencement of metronidazole were consistent with a diagnosis of BV. Effectiveness of metronidazole therapy was likewise much lower than previously reported in studies not restricting enrollment to HSV-2-seropositive women; we observed a BV recurrence rate of 89% in the capital month after completion of therapy during the time that the median time to this resort occurred only 14days after treatment.


Our study demonstrates BV recalcitrance among HSV-2-infected women and provides supplemental evidence for a linkage between this deep-seated viral infection and abnormal vaginal vegetation. Additional work will be needed to circumscribe mechanisms responsible for this correlation and to fix if vaginal flora health of HSV-2-infected women is improved ~ dint of. medications that suppress HSV-2 shedding.

© 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology.

J Obstet Gynaecol Res. 2012 Jan;38(1):77-83. doi: 10.1111/j.1447-0756.2011.01697.x. Epub 2011 Dec 5. synopsis of;jsessionid=54A78C4B43F9813B882574F362F23AC8.f04t03

Md. Rodolfo Vicetti. Ex-miembro del GII.

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