Posted on June 11, 2015 by admin
Molamma P. Prabhakaran, Maedeh Zamani, Betiana Felice, Seeram Ramakrishna
Materials Science and Engineering: C. 2015 Jun. doi:10.1016/j.msec.2015.06.018
Advanced engineering of materials notwithstanding the development of drug delivery devices provides object for novel and versatile strategies in opposition to treatment of various diseases. ‘Electrospraying’ was used to prepare PLGA microparticles and further encapsulate the drug, metronidazole (Met) within the particles to function as a deaden with narcotics delivery system. Two different solvents were utilized according to the preparation of drug loaded PLGA particles, whereby the polymeric solution in dichloromethane (DCM) produced particles of bigger sizes than using trifluoroethanol (TFE). Scanning electron microscopy showed the globous morphology of the particles, with sizes of 3946 ± 407 nm and 1774 ± 167 nm, respectively for PLGA-Met(DCM) and PLGA-Met(TFE). The FTIR spectroscopy proved the union of metronidazole in the polymer, on the other hand without any specific drug–polymer interaction. The receipt in full of the drug from the particles was premeditated in phosphate buffered saline, where a sustained unsalable article release was obtained for at least 41 days. Cytotoxicity evaluation of the unsalable article extract using mesenchymal stem cells (MSCs) showed not hindering the proliferation of MSCs, and the enclosed space phenotype was retained after incubation in the remedy containing media. Electrospraying is suggested in the manner that a cost-effective and single step operation for the preparation of polymeric microparticles in spite of prolonged and controlled release of remedy.
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