Posted in Flagyl on July 7, 2015

Clinical Infectious Diseases, 07/06/2015

Rokas KEE, et al. – The authors aimed to evaluate human race among critically ill patients with Clostridium difficile taint (CDI) who received oral vancomycin (monotherapy) vs verbal vancomycin with intravenous (IV) metronidazole (mixture therapy). The data are supportive of the conversion to an act of combination therapy with oral vancomycin and IV metronidazole in critically very unwell patients with CDI.


A one only-center, retrospective, observational, comparative study was performed.

Patients with a positive C. difficile assay who believed oral vancomycin while bedded in each intensive care unit (ICU) between June 2007 and September 2012 were evaluated.

Patients collection of people ≥3 of the following criteria were included: albumin 90 bpm, narrow arterial pressure 60 years, serum creatinine ≥1.5 general condition of affairs baseline, or temperature ≥100.4°F.

Patients in the complot therapy group received IV metronidazole inside 48 hours after initiating vancomycin.


The primordial outcome was in-hospital mortality.

Patients were matched using Acute Physiology and Chronic Health Evaluation II scores.


Eighty-eight patients were included, 44 in eddish. group.

Patient characteristics were similar although more patients in the combination assemblage had renal disease.

Mortality was 36.4% and 15.9% in the monotherapy and conspiracy therapy groups, respectively (P = .03).

Secondary outcomes of clinical good luck, length of stay, and length of ICU stay did not contend between groups.

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