Posted in Flagyl on October 8, 2015

Helicobacter pylori infection is design to be the most common bacterial bane worldwide. Whilst the prevalence of H. pylori is decreasing swiftly in Europe, Australia and the USA, at which place on average 10-15% of the person of mature age population are infected, it remains a significative problem in China, where serological studies in adults suppress show seroprevalence rates above 70%. Recent premises from Auckland, New Zealand (2012), indicated admirable prevalence of infection in Maori (35%), Pacific peoples (31%) versus Europeans (8%).

H. pylori colonisation is associated with active gastritis but the vast full age (70%) of patients remain asymptomatic. H. pylori  relics on the surface and does not infringe the epithelium of the gastric mucosa.  The bacteria are associated by peptic ulcers, gastric cancer and lymphoma. For an excellent review of upper GIT microbiota including Helicobacter and its associations with disease and health, see  Walker and Talley 2014.  

The primary treatment of H. pylori recommended by the Therapeutic Guidelines is a make threefold therapy combining a proton pump inhibitor (PPI) through amoxycillin and clarithromycin. Unfortunately resistance rates for H. pylori are climbing. Pre-method of treating clarithromycin resistance is currently around 5% to 7%, yet no recent reports from Australia (New Zealand 2012 rates of clarithromycin check were 16%, increasing from 7% in 1999). Previous clarithromycin or azithromycin exposure for other indications increases the probability of secondary resistance and treatment failure.  Regimens by metronidazole are no longer recommended debt to resistance rates of over 50%.

When preparatory eradication therapy fails,  higher rates of clarithromycin check are seen and alternative antibiotics are needed. Usually the clarithromycin is replaced through levofloxacin or rifabutin. If these therapies neglect a quadruple regimen containing bismuth, tetracycline and metronidazole can be used.

Resistance to H. pylori is a expanding concern across the world. A decreased potency to treat H. pylori may decision in increased rates of gastric cancer. A recent systematic review in the BMJ suggested that increasing the duration of treatment, using probiotic supplements, using levofloxacin principal line or using sequential treatments whither one schedule is used after another might be better options for manipulation.

Important questions remain that are exceedingly relevant to patients and antimicrobial stewardship:

What are the longterm personal estate of Helicobacter treatment on gastrointestinal microbiota,  microbiota-kin diseases and colonisation or infection through antimicrobial resistant pathogens?

Will future randomised trials strengthen the suggested benefit of probiotic-supplemented Helicobacter treatments?

Can we efficiently mark patients who have antibiotic resistant  Helicobacter  infections to dwarf unneeded exposure to fluoroquinolone antibiotics that are such important therapeutic agents instead of Gram negative infection?

Can we change into community macrolide (clarith/azithromycin) usage ~ the agency of taking a more critical approach to the broadspread habit of these agents in respiratory and sexual hale condition medicine.  Such reductions may at that time reduce resistance in Helicobacter.

What do current Australian Helicobacter antimicrobial susceptibility representation and what prevalence trends are occurring, especially amongst Aboriginal and Torres Strait Islander groups?

Thanks Prof Marjorie Walker with regard to your input on this posting! 

Other references

Helicobacter pylori uprooting – an update on the latest therapies – 2014, RACGP

Guide to Helicobacter detection- Royal Adelaide Hospital

 Abstract from Walker and Talley 2014:


Categories: FAQ-ventral infection | Tags: antimicrobial resistance, Antimicrobial stewardship, Helicobacter | Permalink.

Author: mdjkf

Microbiologist and Infectious Diseases Physician

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