Posted in Flagyl on December 15, 2015

Have you through all ages had to take two or greater degree drugs for a particular ailment and ground out that instead of just getting rid of the initial symptoms you are having you fit to experience new symptoms unrelated to the ail you wanted treatment for?

Or you probably are taking drug treatment for a minute medical complaint, all seems to have existence going well until you suddenly take you medication with a particular food you love and then your body starts misbehaving big time!

The overhead scenarios are good examples of the sort of is refered to in medical parlance as DRUG INTERACTIONS.

In theory, a deaden with narcotics interaction is a situation in which a substance (drug, food or herbs if it be not that usually drugs) affects the activity of a medicine when both are administered together. Such interactions have power to produce any one of the following results:

Increase the suit of the drug beyond what is expected

Decrease the affair of the drug and make it therapeutically not so much potent.

Produce an entirely new, sudden action (this happens often)

Drug interactions has ponderous consequencies and in countries where reports of unsalable article interactions are monitored and well documented (e.g United states and Europe) it is seen to have ~ing amongst the top 5 leading effect of death.

Over the coming months, using this DRUG ALERT course, we’ll expantiate on dangerous mix with ~s interactions not frequently documented and monitored in the limits of the Nigerian context but still grant pose great health challenges both to soundness care providers and the general the many.

We’ll start with popular handling used for common complaints and ailments today.

1.    Drug Treatment For Malaria and Typhoid

You require a fever and you go pay a ~ to the hospital. Hospital runs some tests without interrupti~ you and confirm you’ve got malaria infection along with typhoid. You recieve your prescript and you are given arthemeter/lumefantrin fixed dose combination antimalaria to tackle the miasm along with ciprofloxacin tablets to ameliorate you get rid of the resembling typhus infection, paracetamol and a few practice vitamins. 

All is well erect? Hmmm…. not really.


Arthemeter/Lumefantrin fixed drench combination antimalarials are powerful antimalarials through potent activity against malaria. But they chouse have one particular unwanted action (amongs other series of adverse effects), the lumefantrin element has this low to average in posse of prolonging the QT interval of the will (this is seen when cardiac sprightliness is measured with an electrocardiogram to fix how well the heart is functioning). A lengthening of the QT interval is cheerful marker for the occurrence of disorderly heart beats and a serious expose to danger factor for sudden death!

Ciprofloxacin is in addition a potent antibiotic useful in treating a large range of infections including typhoid febrile affection. Side effects of ciprofloxacin in adults are highly mild, one would think the unsalable article is as safe as water. Ciprofloxacin nevertheless has this same low to average potential of also prolonging the QT term of the heart.

When these couple drugs are given seperately, the potential for irregular heart beats to occur is grave. But when given together as seen in the usage of malaria and typhoid infections, the in posse to cause irregular heart beat and unusual death increases exponentially. This is a greater reaction of the arthemeter/lumefantrin in addition Ciprofloxacin drug combination that necessitates the exact avoidance of concomittant usage of these sum of ~ units drugs together.

This reactions occur regularly but that are undocumented locally. If you be favored with ever seen or heard of someone heart treated for malaria and typhoid by this drug combination and death occurs pop even while there is evidence of clinical redemption, this reaction is most likely the malefactor.  


Ok, in the way that you ate something nice (you not at any time knew would upset your stomach) a hardly any hours ago and your stomach starts complaint. You reach out for first prosper and grab yourself some mist magnesium trisilicate postponement, tetracycline and probably metronidazole tablets ( we apprehend this as flagyl). You swallow them abstinence from food!  

Still, it gets worse and you examine the hospital, hospital runs a hardly any test just to confirm you put on’t have anything major, they in all probability give stronger antibiotics along with medicines to lodge your intestine from contracting too strong. They also give you some added antacids containing magnesium trisilicate or you are told to truly continue with the Mist magnesium trisilicate suspension you have along with other prescribed drugs. Hmmmmm….


As lengthy as you are taking all those manipulation with Mist. magnesium trisilicate or at all other antacids for that matter, in unembellished terms the treatment will most in a fair way fail. Why? 

Magnesium trisilicate, considerably useful as an antacid covalently binds to antibiotics such as tetracyclines and a lot other drugs to diminish their expected activity and therapeutic originate. This could lead to unrelenting bouts of bear upsets and stomach complaints.

To impede this from happening when you are to take your medication through an antacid preparation, take those drugs at smallest 2 hours after using any antacid state of being prepared and also make sure you exercise the antacid at least 5 hours in the rear of using your drugs.


Paracetamol should with appearance of truth be the most widely used unsalable article product in the world today. It comes in expert for headaches, aches, body pains, fevers etc. Paracetamol is so frequently used that people take beneficial to granted what this popular medicine be able to do.

You are at a party, you’ve had some glasses of alcoholic liquid, all is going fine until you set on foot to notice you’ve got this mollifying headache here or body pain there. You grab two tablets of paracetamol (everybody has it in there bags nowadays), pop it open and into disrepute it with water.This is how you usually handle aches and twinge whenever they happens. Its all excellent right?!


Paracetamol and ethanol (propitious in alcoholic beverages) do not ~ on foot particular well when taken together. Infact spirits of wine alters how paracetamol is broken downward in the liver and in likewise doing increases the concentration of hazardous metabolites of paracetamol in the liver and kidneys. This unfortunately is common cause of chronic liver disease and kidney distemper. Even though not well documented in Nigeria, it is a often seen causative factor in diagnosis in quest of liver disease and chronic kidney failure.

We’ll last with more articles on our DRUG ALERT sequence….so stay tuned

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