Posted in Flagyl on December 6, 2015

Amoebic liver imposthume is a collection of pus in the liver in replication to an intestinal parasite.


Amebic liver imposthume is caused by Entamoeba histolytica. This is the corresponding; of like kind parasite that causes amebiasis, an intestinal infection that is also called amebic dysentery. After an infection has occurred, the toad-eater may be carried by the royal lineage from the intestines to the liver.

The complaint spreads from eating food or wet that has been contaminated with feces (at intervals due to the use of human stripped as fertilizer). It is also spread from one side person-to-person contact.

The contamination occurs worldwide, but is most common in tropical areas where crowded ecclesiastical ~ conditions and poor sanitation exist. Africa, Latin America, Southeast Asia, and India desire significant health problems from this ail.

Risk factors for amebic liver abscess include:



Immunosuppression including HIV contagion


Old age


Recent journey to a tropical region

Steroid use


There are usually no symptoms of of the intestines infection. But persons with amebic liver abscess do have symptoms, including:

Abdominal worry, particularly in the right, upper ingredient of the abdomen; pain is stretched, continuous or stabbing


Fever and chills

Diarrhea (in barely one-third of patients)

General disquiet, uneasiness, or ill feeling (malaise)

Hiccups that finish not stop (rare)


Loss of hunger


Weight loss

Diagnostic Considerations

Important considerations

Persistence of vacant place alone after therapy, without associated signs and symptoms, does not signify the need for repeating antibiotic therapy. (See Prognosis.)

The cavitary lesions of amebic liver gathering and hepatocellular carcinoma can be confused, singly in areas of the world in what place the frequency of both conditions is dear.

The absence of a rapid answer to medical therapy warrants further diagnostic evaluation to rule out pyogenic ulcer or hepatoma.

Failure to use luminal agents from tissue amebicides can lead to return to a former state of infection in approximately 10% of patients.

Special concerns

Treat women who lay open hepatic amebiasis during pregnancy with metronidazole, for all that some theoretical risks are involved. No inimical outcomes have been reported in a throughout-term follow-up study of gravid women given metronidazole for trichomoniasis.

Other problems to have ~ing considered

When evaluating patients with suspected amebic hepatic abscesses, in addition consider the following conditions:



Pulmonary indisposition

Differential Diagnoses

Biliary Disease


Echinococcosis Hydatid Cyst

Hepatic Cysts

Hepatic Hemangiomas

Hepatocellular Adenoma

Hydatid Cysts

Liver Abscess


Peritonitis and Abdominal Sepsis

Primary Hepatic Carcinoma

Pyogenic Hepatic Abscesses

Typhoid Fever

Exams and Tests

Tests that may be done include:

Abdominal ultrasound

Abdominal CT scan or MRI

Complete life-~ count

Liver abscess aspiration to corresponding cipher for bacterial infection in the liver abscess

Liver scan

Liver function tests

Serology as far as concerns amebiasis

Stool testing for amebiasis

Medical Care

Most uncomplicated amebic liver abscesses be possible to be treated successfully with amebicidal medicine therapy alone. Use tissue amebicides to uproot the invasive trophozoite forms in the liver. After accomplishment of treatment with tissue amebicides, administer luminal amebicides in spite of eradication of the asymptomatic colonization express . Failure to use luminal agents can lead to relapse of infection in about 10% of patients.

In general, metronidazole, tinidazole, emetine, and dehydroemetine are diligently employed in invaded tissues; chloroquine is notable only in the liver; tetracycline acts on the bowel wall; and diloxanide furoate, paromomycin, and iodoquinol are luminal agents simply. The details on tissue and luminal amebicidal agents are discussed in Medication.


Metronidazole dead body the drug of choice for amebic liver pustule. Metronidazole enters the protozoa by passive diffusion and is converted to reactive cytotoxic nitroradicals by reduced ferredoxin or flavodoxin. Tinidazole, another nitroimidazole closely related to metronidazole, was approved as being the treatment of amebic liver imposthume and invasive amebiasis. Tinidazole is well tolerated by patients. Tinidazole may be administered once daily and appears to be at in the smallest degree as effective as metronidazole, with a clinical reparative rate of more than 90%.

Metronidazole, 750 mg 3 seasons a day orally for 10 days, was reported to be curative in 90% of patients with amebic liver abscess. The drug moreover is available for intravenous administration in quest of those patients who are unable to take medication ~ the agency of the oral route.

Resolution of symptoms is fairly brisk and is observed within 3 days in ~ numerous patients in the United States. In endemic disease areas outside the United States, it takes comparatively longer to resolve symptoms because the abscesses are to a great extent large or multiple by the time patients look after medical attention.

In vivo resistance to metronidazole by E histolytica has not been reported. Nevertheless, in vitro studies obtain shown an association between metronidazole resistance and decreased expression of ferredoxin 1 and flavodoxin and increased form of words of iron-containing superoxide dismutase and peroxiredoxin in E histolytica.

Usual unlucky effects of metronidazole include nausea, cephalalgy, and metallic taste. Abdominal cramps, vomiting, diarrhea, and dizziness furthermore may occur. Dark urine may occur from a metabolite of the unsalable article.

Other items to consider

Other considerations include the following:

No randomized controlled trials exist that demonstrate the benefits of coalition therapy over monotherapy.

Outside the United States, other closely kin amebicidal agents, such as secnidazole or ornidazole, can be substituted in appropriate dosages. These drugs are not available in the United States.

Chloroquine phosphate may have ~ing substituted or added in the marked occurrence of failure of resolution of clinical symptoms by metronidazole or another nitroimidazole within 5 days or intolerance to metronidazole or a nitroimidazole. Chloroquine has the inconvenience of being associated with higher falling back rates than nitroimidazoles. Adverse effects contain gastrointestinal upset, headache, dizziness, and blurred appearance. Retinopathy does not occur at the dose used for amebic liver abscess.

Emetine or dehydroemetine has a superscribe lethal action on the trophozoites ofE histolytica. These agents are exceedingly toxic and, therefore, should be used barely as a second-line therapy. Their toxicity includes cordial arrhythmias, precordial pain, muscle weakness, vomiting, and diarrhea. Dehydroemetine is not so much toxic than emetine.

Administer a luminal amebicidal actor to eradicate the intestinal carriage hinder the amebic liver abscess has been treated by one of the above tissue amebicides. Failure to practice luminal agents can lead to lapse of infection in approximately 10% of patients. Luminal agents with proven efficacy include diloxanide furoate, iodoquinol, and paromomycin. Note the following:

Diloxanide furoate is munificent of major adverse effects. The principally common adverse effect is flatulence and causing gastrointestinal upset.

Iodoquinol (diiodohydroxyquin) rarely causes ventral pain, diarrhea, or rash. A structurally allied diiodohydroxyquin caused subacute myelopticoneuropathy and is obsolete now.

Although paromomycin may occasionally object nausea, abdominal cramps, or diarrhea, it is the preferred luminal amebicidal.

The minor circumstances on the luminal amebicides are discussed in Medication.


Consult with an interventional radiologist for imaging-guided yearning of the abscess.

Consult with a of the whole surgeon for open surgical drainage of the gathering under rare circumstances (see Surgical Care).

Diet and agility

No specific diet change or alteration is required. However, discuss food hygienics with patients because amebiasis is associated with suboptimal personal or food hygiene (look Deterrence/Prevention).

No restriction of activity is needed, except during the at the outset few days of acute illness by pain.

If emetine or dehydroemetine is used, the sufferer should remain sedentary for approximately 4 weeks in the pattern of completing therapy because of their toxicity.

surgical care

Consider therapeutic aspiration of amebic liver abscess in the following situations: (1) transcendental risk of abscess rupture, as defined ~ means of cavity size greater than 5 cm; (2) left lobe liver abscess, which is associated with higher subjection to death and frequency of peritoneal leak or hostility into the pericardium; (3) failure to adhere to a clinical medical response to therapy in the compass of 5-7 days; and (4) cannot differentiate from a pyogenic liver ulcer.

The following are predictive of the stand in want of for aspiration: (1) age older than 55 years, (2) ulcer greater than 5 cm in central chord, and (3) failure of medical therapy in the pattern of 7 days.[25] In endemic disease areas, because of the late show and the existence of multiple abscesses, while many as 50% of patients may claim aspiration.[26]However, routine needle craving offers only minimal benefit over medical care alone for uncomplicated amebic liver gathering and, unless one of the aloft indications exists, should be avoided.[27] Prompt curative care decreases the need for craving.[28]

Imaging-guided needle aspiration and catheter drainage are the procedures of sparing. Generally, surgical drainage is not requisite and should be avoided; however, be attentive to open surgical drainage when the gathering is inaccessible to needle drainage or a rejoinder to therapy has not occurred in 5-7 days.

Simple needle ardent wish is less invasive, is less lavish, and has the advantage of subsistence able to drain multiple abscesses in the sort session. Simple needle aspiration avoids problems cognate to catheter care (see Procedures).

Although catheter drainage may subsist more effective than needle aspiration, in a study ~ dint of. Rajak et al,[29] the mean proportion time for clinical improvement, mean hospital stay, and time to solution were similar among the patients who were fortunately treated in the 2 treatment groups.

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