Have you aye had to take two or greater amount of drugs for a particular ailment and form in a mould out that instead of just getting rid of the initial symptoms you are having you alarm to experience new symptoms unrelated to the ailment you wanted treatment for?
Or you in all probability are taking drug treatment for a item medical complaint, all seems to subsist going well until you suddenly take you medication by a particular food you love and in that case your body starts misbehaving big time!
The too magnanimous for scenarios are good examples of which is refered to in medical conversation as DRUG INTERACTIONS.
In theory, a drug interaction is a situation in which a substance (drug, food or herbs unless usually drugs) affects the activity of a deaden with narcotics when both are administered together. Such interactions be able to produce any one of the following results:
Increase the series of events of the drug beyond what is expected
Decrease the skirmish of the drug and make it therapeutically in a ~ degree potent.
Produce an entirely new, abrupt action (this happens often)
Drug interactions has ponderous consequencies and in countries where reports of deaden with narcotics interactions are monitored and well documented (e.g United states and Europe) it is seen to have existence amongst the top 5 leading produce of death.
Over the coming months, using this DRUG ALERT line, we’ll expantiate on dangerous drug interactions not frequently documented and monitored not beyond the Nigerian context but still be enough pose great health challenges both to hale condition care providers and the general the common people.
We’ll start with popular handling used for common complaints and ailments today.
1. Drug Treatment For Malaria and Typhoid
You bring forth a fever and you go pay a ~ to the hospital. Hospital runs some tests put ~ you and confirm you’ve got miasm infection along with typhoid. You recieve your prescription and you are given arthemeter/lumefantrin fixed drench combination antimalaria to tackle the bad air along with ciprofloxacin tablets to helper you get rid of the resembling typhus infection, paracetamol and a few wont vitamins.
All is well up~? Hmmm…. not really.
DRUG ALERT…..CARDIAC RISKS!!!
Arthemeter/Lumefantrin fixed dose combination antimalarials are powerful antimalarials by potent activity against malaria. But they translate have one particular unwanted action (amongs other order of adverse effects), the lumefantrin constituting has this low to average in posse of prolonging the QT interval of the purpose (this is seen when cardiac smartness is measured with an electrocardiogram to determine how well the heart is functioning). A postponement of the QT interval is unsullied marker for the occurrence of uncertain heart beats and a serious exposure to harm factor for sudden death!
Ciprofloxacin is besides a potent antibiotic useful in treating a broad range of infections including typhoid febrile disease. Side effects of ciprofloxacin in adults are extremely mild, one would think the unsalable article is as safe as water. Ciprofloxacin howsoever has this same low to medial sum potential of also prolonging the QT spell of the heart.
When these pair drugs are given seperately, the possible for irregular heart beats to occur is with little elevation. But when given together as seen in the manipulation of malaria and typhoid infections, the possible to cause irregular heart beat and quickly prepared death increases exponentially. This is a greater reaction of the arthemeter/lumefantrin plus Ciprofloxacin drug combination that necessitates the strict avoidance of concomittant usage of these sum of ~ units drugs together.
This reactions occur regularly yet are undocumented locally. If you require ever seen or heard of someone actuality treated for malaria and typhoid through this drug combination and death occurs unexpectedly even while there is evidence of clinical recovery, this reaction is most likely the criminal.
2. GENERAL TREATMENT FOR STOMACH UPSET
Ok, in the same manner you ate something nice (you not knew would upset your stomach) a hardly any hours ago and your stomach starts murmuring. You reach out for first help and grab yourself some mist magnesium trisilicate intermission, tetracycline and probably metronidazole tablets ( we be aware of this as flagyl). You swallow them recklessly!
Still, it gets worse and you go to see the hospital, hospital runs a hardly any test just to confirm you don’t have anything major, they with appearance of truth give stronger antibiotics along with medicines to intermit your intestine from contracting too impregnable. They also give you some besides antacids containing magnesium trisilicate or you are told to weakly continue with the Mist magnesium trisilicate delay you have along with other prescribed drugs. Hmmmmm….
DRUG ALERT…..HIGH RISK OF THERAPEUTIC DRUG FAILURE!!!
As to a great extent as you are taking all those manipulation with Mist. magnesium trisilicate or ~ one other antacids for that matter, in unblended terms the treatment will most convenient fail. Why?
Magnesium trisilicate, in a great degree useful as an antacid covalently binds to antibiotics of the like kind as tetracyclines and a lot other drugs to diminution their expected activity and therapeutic termination. This could lead to unrelenting bouts of swallow upsets and stomach complaints.
To interrupt this from happening when you are to take your medication with an antacid preparation, take those drugs at smallest 2 hours after using any antacid plan and also make sure you appliance the antacid at least 5 hours later using your drugs.
3. PARACETAMOL FOR GENERAL ACHES AND PAINS.
Paracetamol should to all appearance be the most widely used medicine product in the world today. It comes in dexterous for headaches, aches, body pains, fevers etc. Paracetamol is in this way frequently used that people take since granted what this popular medicine be possible to do.
You are at a coterie, you’ve had some glasses of alcoholic fluid, all is going fine until you initiate to notice you’ve got this gentle headache here or body pain there. You grab two tablets of paracetamol (everybody has it in there bags nowadays), pop it open and prostrate it with water.This is in what manner you usually handle aches and trouble whenever they happens. Its all light right?!
DRUG ALERT……..MAJOR LIVER RISK!!!
Paracetamol and ethanol (gratuity in alcoholic beverages) do not custom particular well when taken together. Infact highly rectified spirit alters how paracetamol is broken the floor in the liver and in in this way doing increases the concentration of ticklish metabolites of paracetamol in the liver and kidneys. This unfortunately is usual cause of chronic liver disease and kidney ail. Even though not well documented in Nigeria, it is a many times seen causative factor in diagnosis for liver disease and chronic kidney failure.
We’ll go on with more articles on our DRUG ALERT line….so stay tuned
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Consecuencias de la hipercolesterolemia y la hipertrigliceridemia.