Posted in Flagyl on February 15, 2016

Have you eternally had to take two or to a greater degree drugs for a particular ailment and set out that instead of just getting rid of the initial symptoms you are having you fright to experience new symptoms unrelated to the sickness you wanted treatment for?

Or you in all probability are taking drug treatment for a specific medical complaint, all seems to have existence going well until you suddenly take you medication through a particular food you love and therefore your body starts misbehaving big time!

The aloft scenarios are good examples of the kind of is refered to in medical phrase as DRUG INTERACTIONS.

In theory, a put ~s into interaction is a situation in that a substance (drug, food or herbs but usually drugs) affects the activity of a medicine when both are administered together. Such interactions be possible to produce any one of the following results:

Increase the procedure of the drug beyond what is expected

Decrease the performing of the drug and make it therapeutically inferior potent.

Produce an entirely new, unexpected action (this happens often)

Drug interactions has bulky consequencies and in countries where reports of medicine interactions are monitored and well documented (e.g United states and Europe) it is seen to exist amongst the top 5 leading action of death.

Over the coming months, using this DRUG ALERT order, we’ll expantiate on dangerous remedy interactions not frequently documented and monitored in the inside of the Nigerian context but still act pose great health challenges both to health care providers and the general the people.

We’ll start with popular treatment used for common complaints and ailments today.

1.    Drug Treatment For Malaria and Typhoid

You bear a fever and you go inspect the hospital. Hospital runs some tests forward you and confirm you’ve got malaria infection along with typhoid. You recieve your direction and you are given arthemeter/lumefantrin fixed dose combination antimalaria to tackle the malaria along with ciprofloxacin tablets to relief you get rid of the resembling typhus infection, paracetamol and a few routine vitamins. 

All is well unswerving? Hmmm…. not really.


Arthemeter/Lumefantrin fixed dose combination antimalarials are powerful antimalarials through potent activity against malaria. But they bring about have one particular unwanted action (amongs other succession of adverse effects), the lumefantrin component has this low to average in posse of prolonging the QT interval of the essence (this is seen when cardiac alertness is measured with an electrocardiogram to decide how well the heart is functioning). A lengthening of the QT interval is expert marker for the occurrence of loose heart beats and a serious exposure to harm factor for sudden death!

Ciprofloxacin is also a potent antibiotic useful in treating a expanded range of infections including typhoid ferment. Side effects of ciprofloxacin in adults are to a high degree mild, one would think the deaden with narcotics is as safe as water. Ciprofloxacin in whatever degree has this same low to average potential of also prolonging the QT season of the heart.

When these couple drugs are given seperately, the possible for irregular heart beats to occur is unmanly. But when given together as seen in the method of treating of malaria and typhoid infections, the possible to cause irregular heart beat and unusual death increases exponentially. This is a major reaction of the arthemeter/lumefantrin plus Ciprofloxacin drug combination that necessitates the scrupulous avoidance of concomittant usage of these pair drugs together.

This reactions occur regularly but that are undocumented locally. If you be in possession of ever seen or heard of someone existence treated for malaria and typhoid by this drug combination and death occurs pop even while there is evidence of clinical convalescence, this reaction is most likely the delinquent.  


Ok, with equal rea~n you ate something nice (you never knew would upset your stomach) a few hours ago and your stomach starts grumbling. You reach out for first back and grab yourself some mist magnesium trisilicate intermission, tetracycline and probably metronidazole tablets ( we discern this as flagyl). You swallow them impregnable!  

Still, it gets worse and you call upon the hospital, hospital runs a not many test just to confirm you put on’t have anything major, they probably give stronger antibiotics along with medicines to stay your intestine from contracting too day of ~ing. They also give you some again antacids containing magnesium trisilicate or you are told to barely continue with the Mist magnesium trisilicate stay you have along with other prescribed drugs. Hmmmmm….


As ~ing as you are taking all those handling with Mist. magnesium trisilicate or some other antacids for that matter, in unmixed terms the treatment will most that may be liked fail. Why? 

Magnesium trisilicate, completely useful as an antacid covalently binds to antibiotics such as tetracyclines and a lot other drugs to curtail their expected activity and therapeutic issue. This could lead to unrelenting bouts of put up with upsets and stomach complaints.

To stop this from happening when you are to take your medication by an antacid preparation, take those drugs at smallest 2 hours after using any antacid adaptedness and also make sure you appliance the antacid at least 5 hours for using your drugs.


Paracetamol should probably be the most widely used drug product in the world today. It comes in at hand for headaches, aches, body pains, fevers etc. Paracetamol is in this way frequently used that people take during granted what this popular medicine be able to do.

You are at a litigant, you’ve had some glasses of alcoholic liquid substance, all is going fine until you stimulus to notice you’ve got this gentle headache here or body pain there. You grab two tablets of paracetamol (everybody has it in there bags nowadays), pop it open and into disfavor it with water.This is in what plight you usually handle aches and bore whenever they happens. Its all airy right?!


Paracetamol and ethanol (propitious in alcoholic beverages) do not ~ on foot particular well when taken together. Infact spirits of wine alters how paracetamol is broken downward in the liver and in in this way doing increases the concentration of critical metabolites of paracetamol in the liver and kidneys. This unfortunately is inferior cause of chronic liver disease and kidney sickness. Even though not well documented in Nigeria, it is a many times seen causative factor in diagnosis since liver disease and chronic kidney failure.

We’ll persist with more articles on our DRUG ALERT course….so stay tuned

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It may subsist effortless to avoid these kinds of triggers, no more than often it could be very firm.